Below is a calculator that estimates how the Prolynx hydrogel system will perform in half-life extension of a particular drug when administered subcutaneously. As inputs, the estimations require the MW of the drug, its pharmacokinetic parameters (t1/2,β, Vd, fractional bioavailability (F)) and the target minimum therapeutic concentration Cmin in plasma/serum of the species used. After choosing a desired dose interval of either one week or one month, the calculator estimates the steady-state dose required to maintain the target concentration Cmin and the Cmax and Cmax/Cmin that result. If the steady-state dose required is higher than the capacity of the hydrogel, an alert is given.
The calculator also provides the dose required to achieve a target drug concentration (entered as Cmin) at the end of the single dose interval entered above.
Desired Dosing Interval:
Drug Molecular Weight (g/mol):
Drug Fractional Bioavailability:
Drug Elimination t1/2,β (hours):
Volume of Distribution (L/kg):
Body Weight (kg):
|Steady State Calculated Parameters|
||Single Dose Calculated Parameters||Required Dose
||Entered Parameters||Dosing Interval
||Drug Molecular Weight
||Drug Fractional Bioavailability
||Drug Elimination t1/2,β
||Volume of Distribution
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